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In an autoimmune context, these responses can cascade into thyroid flares, increased antibody activity, and deepened fatigue that takes weeks to recover from

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A big study in the New England Journal of Medicine found that people taking semaglutide had an average weight loss of 14.9% from their starting weight, including data from healthy subjects

Consistently meeting protein and fiber goals most days, rather than perfectly every day, is typically enough to support muscle preservation, digestion, blood sugar stability, and satiety over time, she says