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A strong letter of medical necessity should include: your BMI history over at least 12 months, documentation of weight-related comorbidities (hypertension, type 2 diabetes or prediabetes, dyslipidemia, sleep apnea), prior weight-loss attempts and their outcomes, the specific clinical trial data supporting the requested medication, and a statement that the medication is medically necessary (not cosmetic)

This support enables you to keep the weight off even if you eventually stop taking the medication

These shifts may improve outcomes and justify larger trials testing durability beyond 32 weeks and generalizability, including effects on mortality benefits

To protect muscle mass When calorie intake drops quickly, it is not just body fat that can be lost

For context on how age-related changes affect peptide function, the discussion of longevity peptides provides useful background