[1] Additionally, the authors indicate that there is still a requirement for successful human trials to be completed prior to clinical translation as there are important differences between rodent and human physiology that could have a significant impact on the efficacy and safety of any agent
The structures of the main metabolites of [3H]BPC157 in rat plasma, bile, urine, and feces were analyzed and identified using LC-MS/MS and standard molecular weight comparison
PMID 8719443
Peripheral neuropathy, subacute combined degeneration of the spinal cord, or cognitive impairment indicate more advanced deficiency and generally require intensive treatment over extended periods
Bisphosphonates end in the suffix -dronate or -dronic acid (e.g., alendronate, risedronate, pamidronate) and bind to hydroxyapatite crystals in bone, inhibiting osteoclast-induced bone resorption