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Furthermore, PR-104 has been shown to reduce all cells with high AKR1C3 expression in the bone marrow rapidly, making it a compelling treatment strategy for T-ALL patients characterized by AKR1C3 overexpression and hypoxia (Moradi Manesh et al., 2015)

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3.1 Molecular mechanisms of ferroptosis Ferroptosis is intricately linked to intracellular metabolism involving amino acids, lipids, and iron

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It is also abnormally low in ME/CFS patients (308, 309)