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In addition, individuals who may be vitamin K deficient due to liver failure, those with a propensity to bleed (e.g., bleeding peptic ulcers), and those with inherited bleeding disorders (e.g., hemophilia) or a history of hemorrhagic stroke, should not take -tocopherol supplements without close medical supervision because of the increased risk of hemorrhage (119, 128)
Importantly, no serious adverse events were reported in the semaglutide group, and no one had to stop the trial due to side effects
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However, no research directly compares continuous use versus cycling protocols (such as 12 weeks on, 4-8 weeks off), leaving optimal long-term strategies somewhat uncertain