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Conclusion As the multi-hit hypothesis holds, combining the therapeutic approaches of GLP-1 agonists with resmetirom seems like a promising strategy by targeting the multifaceted pathophysiology of MASH, which may lead to improved patient outcomes

Kanofsky JR (1989) Singlet oxygen production by biological systems

Oxidative stress can induce nuclear DNA activation, which leads to the initiation of cancer

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Similar fragility applies to tirzepatide , which shares structural complexity as a fellow GLP-1 receptor agonist