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And so having this in our arsenal in my tool bag has been a game changer

The first strategy is by inhibiting the activity of the dipeptidyl peptidase-4 by DPP-4 inhibitors

A study examining b.End.3 cells exposed to high glucose levels in vitro demonstrated a dose-dependent increase in permeability, with increased HIF-1 and decreased expression of the TJ proteins, ZO-1 and occludin (Yan et al., 2012)