Their hydroxyl-rich structures enable electron donation to neutralize free radicals, while MAPK/Nrf2 signaling upregulates antioxidant enzymes such as SOD and GSH-Px (Singh et al., 2021)
In contrast, GPx2 focuses on the gut, acting as a barrier against oxidants from food, which is why its abundant in intestinal cells
doi: 10.1111/j.1365-2958.1991.tb00813.x 32 BiesbroekG.TsivtsivadzeE.SandersE
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