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Dose adjustment is not recommended in patients with mild-severe renal impairment (eGFR = 15-89 mL/min/1.73 m 2 ), but use is not recommended for patients with end-stage renal disease (127)

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Patients with Crohns disease who take glucocorticoids have a higher risk of fractures compared to those who do not (Bernstein 2003)

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