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According to the Centers for Disease Control the percentage of adult Americans who smoke has declined since 1965 from 42.4% to 18.9% in 2011, but the rate has leveled off in recent years

PDF page 19 of the Guide tells doctors and other health care providers that: "Pharmacotherapy is recommended for all dependent smokers who express an interest in quitting, except where contraindicated." Doctors are told that "first line options are medicines that have been shown to be effective" and in "Australia these are NRT (brands include Chemist's Own Nicotine, Nicabate CQ, Nicorette, Nicotinell, QuitX and others), varenicline (brand name Champix) and sustained release preparations of bupropion hydrochloride (brand names Buproprion-RL, Clorprax, Prexaton and Zyban SR)." PDF page 29 tells physicians that "all forms of NRT (at equivalent doses) are similarly effective in aiding long term cessation," that "all forms of NRT can increase the rate of quitting by 50-70 percent." Not once does the Guide warn doctors that NRT's 50-70% rate reflects efficacy over placebo, findings from studies that we now know were not blind as claimed

In fact, evidence strongly suggests that they may actually increase a smokers risk of developing a type of non-small cell lung cancer called lung adenocarcinoma

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