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In addition, in exposure models, the selection of the exposure dose (e.g

One systematic review concluded that smoking significantly increases periprosthetic intra-articular space infection and surgical wound complications in primary hip and knee joint replacement surgeries 12

For example, NRTs can cause skin irritation, sleep disturbances, and gastrointestinal issues, among others

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However, there is a concern, particularly for adolescents, that the use of e-cigarettes may cause an increase in established smokers in the future [16]