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This study showed that at the end of the first peak, the primary infection rates of the current smokers, ex-smokers, non-smokers, and entire population were 58.1%, 69.0%, 74.4%, and 69.7%, respectively

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[103] The National Institute for Clinical Excellence came to a different conclusion, they pointed out the problems of using uncontrolled clinical trials to assess the effectiveness of pharmacotherapy and based on placebo-controlled research they concluded that benzodiazepines were not effective in the long-term for panic disorder and recommended that benzodiazepines not be used for longer than 4 weeks for panic disorder