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Last month the UK Supreme Court refused the tobacco industry leave to appeal the decision any further

The effectiveness of nicotine replacement therapies in smoking cessation

Very recently, the applicants have isolated the oxidant from cigarette smoke/tar solution and identified it as a major potentially hazardous compound, which almost quantitatively accounts for the oxidative damage of proteins caused by cigarette smoke solution

These changes lead to an increased dose-response relationship meaning an increase in symptoms with increased exposure to nicotine

Tob Control 20:353360 Gendall P et al (2011) Young adults interpretations of tobacco brands: implications for tobacco control