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In CD, infiltrating CD4 + T cells produce a large number of Th1/Th17-associated pro-inflammatory cytokines such as IFN-, IL-17A, and TNF- ( + T cells secrete Th2-associated proinflammatory cytokines, such as IL-4, IL-13, and IL-14 ( NKT cells are also an important part of the immune response in UC pathology: they secrete IL-13, which causes damage in the epithelium, and this consequently generates a positive feedback that increases NKT cell function ( It has been also suggested that humoral immunity has a more relevant etiological role in UC than in CD

For instance, in August 2024, Lost Mary, a UK-based vape products manufacturing company, launched the BM6000 in the UK market

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