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Dollar General, Morningstar Research wrote in a recent analyst report, can meet its customers needs for a low absolute-dollar price point through smaller packages that carry better margins for both the retailer and the manufacturer. Gross margin measures the amount of profit a retailer earns from each sale after accounting for the cost of the product

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Basically, it boils down buying and sell specific stocks before and after you complete the assassination missions for Lester (which are a big part of the single player story line)