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If you do notice an increase in blood pressure, talk to your doctor to make sure youre taking the right dose

The increased myocardial contractility and oxygen demand, coupled with a decrease in coronary blood flow from an increase in coronary vascular resistance, leads to a decrease in the myocardial oxygen supply: demand ratio

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This is consistent throughout the Lupin III franchise, as even his fresh cigarettes are crumpled and bent out of shape

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