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It has been shown that, similar to brain tumors, tumorigenic cells in small cell and non-small cell lung cancer in humans are a rare population of CD133-positive, undifferentiated cancer stem cells that are able to self-renew, grow indefinitely, and repopulate secondary transplanted hosts, whereas CD133- negative tumor cells are not

[11] Research into nicotine's most predominant metabolite, cotinine, suggests that some of nicotine's psychoactive effects are mediated by cotinine

Even moderate drinking can cause oxidative stress in sperm

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