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Thus, in 2023, according to the own data from KPMG reports carried out for the cigarette manufacturer Philip Morris, 4.34 billion cigarettes were sold in Luxembourg, or more than 18 cigarettes per day per inhabitant

It is also recognized that smoke exposure leads to the activation of the Nod-like receptor protein 3 (NLRP3) inflammasome [63], with consequent local generation of active interleukin 1 (IL-1), a process that induces inflammation and thereby can lead to both chronic fibrosis and cancer in mice [64]

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