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When a smokeless or chewing tobacco product, regardless of its form is placed inside your time, it releases harmful constituents like nicotine and makes your mouth a lot of saliva

Additionally, nitrosamines derived from betel quid and tobacco mediating oxidation of thiol group of antioxidants such as glutathione-S-transferase, superoxide dismutase (SOD), glutathione reductase, glutathione peroxidase (GPx), and catalase (CAT) were reported (Shiu and Chen, 2004) to induce changes in oral microbiome communities contributing to oral carcinogenesis (Lee et al., 2017

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At the clinical level, the association between inflammation and induction of cancer has been well established in the case of oral cavity, ovaries, prostate, bladder, liver, pancreas, colon, stomach, and other sites (Rosin et al., 1994

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