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Plain packaging has since been implemented in France (2016), United Kingdom (2016), Norway (2017), Ireland (2017), New Zealand (2018), Saudi Arabia (2019), Turkey (2019), Thailand (2019), Canada (2019), Uruguay (2019), Slovenia (2020), Belgium (2020), Israel (2020), Singapore (2020), Netherlands (2020), Denmark (2021), and Guernsey (2021), Hungary (2022), Jersey (2022), Finland (2023), Mauritius (2023), Oman (2024), Georgia (2025) and Myanmar (2025), with implementation to be required in Iceland (2027) and Syria (2027)

The medication by genotype groups will be compared using mixed models with fixed effects as intervention group (topiramate or naltrexone) and genotype (rs2832407*CC versus A carrier) as a moderating variable

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