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In the STEP8 trial, comparing semaglutide (2.4 mg, weekly subcutaneous injection) with liraglutide (3.0 mg, daily subcutaneous injection) in patients with overweight or obesity and no previous bariatric surgery or T2D, a mean weight change from baseline of 15.8% with semaglutide vs 6.4% with liraglutide after 68 weeks was reported [27]

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Importantly, this heterogeneity is not limited to the magnitude of weight loss, but may also include minimal treatment response, persistent appetite, weight regain, and, in rare cases, paradoxical increases in appetite and food intake

FDA Center for Drug Evaluation and Research

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