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Physicians at each clinic screened the patients and obtained written informed consent

Clozapine had been pulled from the market in the 1970s after fatal cases of severe neutropenia in Finland, but the pivotal Kane and colleagues trial in 1988 showed clozapine to be highly effective for treatment-resistant schizophrenia

Because the UK government is very keen to see their Smokefree by 2030 plan come to fruition, several intended measures were announced by UK Prime Minster Rishi Sunak towards the end of 2023 and by Chancellor Jeremy Hunt in the latest Budget

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This difference highlights the role of nicotine bioavailability, which refers to how much nicotine actually enters the body during use