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This study provides evidence on how chronic inhalation exposure to aerosols from two alternative tobacco products impacts pulmonary inflammatory responses, induces oxidative stress, lung endothelial and epithelial damage, and suppresses the efficacy of vaccine-induced antibacterial immunity leading to increased pathogen burden in the lungs of exposed mice in a manner like combustible cigarette smoke (as graphically depicted in Fig

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Foulds J, Bryant A, Stapleton J, Jarvis MJ, Russell MA (1994)