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This state of uncontrolled inflammation contributes to a cascade of negative effects, including tissue destruction, organ dysfunction, and an increased risk of developing chronic diseases

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For example, low CTR1 expression, as well as high ATP7A expression, are associated with poor platinum-based chemotherapy outcomes 49,50 , while high CTR1 expression correlates with longer progression free survival and overall survival after platinum-based regimens 61,69

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