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The first nicotine product approved by the Food and Drug Administration (FDA) was gum back in 1984

77.Nutt DJ, Phillips LD, Balfour D, Curran HV, Dockrell M, et al

According to Helander et al., in their study Appearance of Hexahydrocannabinols as Recreational Drugs and Implications for Cannabis Drug Testing, published in the Scandinavian Journal of Clinical and Laboratory Investigation (2024) , all three cannabinoids showed varying degrees of cross-reactivity in standard screenings

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