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Down-stream, dendritic cells exposed to smoke migrate poorly to lymph nodes and bias T-cell priming away from protective Th1 immunity, favouring Th2, Th17, and regulatory T-cell profiles marked by exhaustion receptors such as PD-1 and CTLA-4 (Feng et al., 2011

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The tobacco cut is heavier than most domestic full-flavors, which means a denser smoke per draw and a slower burn across the cigarette

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