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The limitations of our present study include the issue that different strains, young Sprague Dawley rats and aged Fischer 344 rats, were used

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EV-mediated cargo transfer to recipient cells affects many stages of cancer progression through communication between the cancer cells and the surrounding tumor microenvironment, such as the promotion of myofibroblast differentiation 33 , activation of proliferative and angiogenic pathways 34 , and initiation of pre-metastatic sites 35,36