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In 1992, the following five sizes were further made in order to commemorate the 500th anniversary of the discovery of Cuba in 1492: Siglo I, II, III, IV and V

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Molecular studies have demonstrated that tobacco combustion products contain potent carcinogens, including polycyclic aromatic hydrocarbons (PAHs) and aromatic amines, which reach the bladder epithelium at high concentrations via urinary excretion, thereby inducing DNA damage 22

ABC News contributed to this report.