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Because the smokers who were treated with clozapine were reported to suffer from substantial central nervous side effects after smoking cessation ( Pharmacogenomics study shown that genetic variants in UGT enzymes, which were responsible for nicotine glucuronidation, were also involved in clozapine metabolism ( Limitations The present studys strengths were the MR design and the utilization of summary-level data from the biggest GWASs to date

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