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In addition to directly activating various inflammatory cells such as MCs, eosinophils, and alveolar macrophages to infiltrate and recruit them in the airways, these cytokines can also aggravate AHR

Although this amount is small compared with the annual economic losses from tobacco ($1.4 trillion per year) and may appear insignificant compared with the 8 million deaths attributable to tobacco each year, these environmental costs should not be downplayed as these are accumulating and are preventable, Sy said in a news release