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It is a result of long-term exposure to nicotine, which causes withdrawal symptoms when not smoking, and difficulty to quit smoking

This short half-life means that frequent use is necessary to maintain the desired effects, which perpetuates the cycle of addiction and makes it challenging to quit without experiencing frequent cravings throughout the day

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Non-small cell lung cancer (NSCLC) includes several subtypes of tumors

Numerous studies on cultured cells showed that nicotine treatment increases cytosolic ROS levels and leads to oxidative stress