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There were upward trends from lower to higher school grades in exclusive cigarette use and cigarette use combined with other products, but the trends were not clear among new alternative products users

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Second, there could be unmeasured variables that account for the associations between early age of cigarette smoking initiation and COPD risk, such as prenatal smoke exposure 26 and unmeasured aspects of cigarette smoking not accounted for by pack years, smoking duration, or current smoking status

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