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The pairwise contrast revealed that mean change was statistically significant when comparing abstinent participants with smokers (mean difference 5.22

A key assumption of permutation tests is exchangeability and therefore, we permuted the exposure conditional on the subject (e.g., exposure was permuted on the HBEC values from a single donor, not across donors) and kept the numbers of permuted observations under each condition the same as the observed results

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Automatic Tobacco Feeding : When the sensor detects a low tobacco level, it automatically feeds the material into the chamber

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