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In a record of 26,961 operations involving the use of general anesthesia, it was found that certain respiratory events, such as re-intubation, laryngospasm, bronchospasm, aspiration, and hypoventilation/hypoxemia occurred at an incidence of 5.5% in tobacco smokers and at an incidence of 3.1% in non-smokers, with the relative risk of these respiratory events being 1.8 in all smokers, 2.3 in young smokers (defined as those between 16 and 39 years of age) , and 6.3 in obese young smokers

37 For selected patients with cardiovascular disease, 37 NRT should be used with caution, because nicotine can increase the heart rate and blood pressure and also act as a coronary vasoconstrictor