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When a person inhales nicotine, it takes approximately 10 seconds for it to reach the brain and for the dopamine release to take effect

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The reason that it is easier is that gravity is not opposing the reflux, as it does in the upright position during the day

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27 The one partial exception is Philip Morris Internationals heat-not-burn product IQOS, which heats tobacco (unlike conventional ENDS, which vaporize an eliquid) without combustion so that the vapor can be inhaled