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Airway epithelial injury induced by acute vaping of PG and glycerol aerosols (50:50 vol/vol), with or without nicotine, has been reported in two randomised clinical trials in young tobacco smokers [32]

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Due to health concerns and the FDA's classification of e-cigarettes as both a drug and a device, the agency intervened and banned all e-cigarette imports into the United States pending further approval (Figure 3) [1,2,5,10,19-25]