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A systematic review found that, generally, tar and nicotine levels were lower among IQOS products than conventional cigarettes

"Restricting access to tobacco products until age 21 should lower the smoking rate in the commonwealth." On such study, an Institute of Medicine report published in March, estimated that raising the legal minimum age to 21 would decrease the rates of tobacco use by 12 percent in today's teenagers by the time they became adults

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Although most dermal reactions to PG are the result of irritation, true immunological reactions have been confirmed through patch testing