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Novel targeted agents are also emerging, including TRK, RET, and NTRK1 inhibitors for cancers driven by fusions in these growth factor genes

Signs of premature skin aging, including acquired cutis laxa of the extremities and skin wrinkling, although less specific, might also help in the differential with hEDS, especially in adults

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Besides, TSLP has been shown to mediate interactions between airway structural cells and inflammatory cells 65