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8 Therapeutic approaches targeting mitochondria in inflammatory lung diseases Pharmacological interventions have been the most widely studied potential therapeutic approach to target mitochondria in inflammatory lung diseases ( NAC has been shown in vitro to prevent mitochondrial permeability transition and cytochrome c release in response to apoptosis-inducing stimuli in a lung epithelial cell line, In a recent in vitro investigation, cigarette smoke-induced CFTR failure hindered alveolar macrophages ability to phagocytose ( in vivo administration in a smoke-exposed rat model of emphysema prevented increases in lung iNOS expression, 3-nitrotyrosine formation, NF-B activation, and alveolar destruction ( Multiple studies have investigated the role of ROS in ALI