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24, pages 13 and 25 December 13, 1963 A long-range study to determine the effect that smoking has on the human body was orderedby the House of Delegates of the American Medical Association So many gaps exist in knowledge about the relationship of smoking to health it is the belief of the board [of trustees of the AMA] that an intensive long-range research program, such as is proposed, is imperative A mass of statistical informationhas been developed indicating certain relationships between smoking: and disease which cannot be ignored , even though the significance of them in terms of cause and effect is still being debated The board recommended that the long-range program be financed by a substantial contribution from the AMA and solicitations from other sources, such as industry, foundations, voluntary health agencies and private physicians The proposed research program would be conducted in three phases, according to the board

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Low-Intensity Smoking Still Raises Major Cardiovascular Risks An extensive review of nearly two dozen long-term studies shows that people who smoke only a small number of cigarettes still face a much higher likelihood of heart disease and early death compared to those who have never smoked