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Smoking appears to have both causal relationships and possible synergistic interactions with other major risk factors for coronary heart disease, including hyperlipidemia, hypertension, and diabetes mellitus [ 54 ]

13 Di GiacomoM.PaolinoM.SilvestroD.VigliottaG.ImperiF.ViscaP.et al (2007)

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4), subsequent analyses combined the two stress subgroups (stress) and two non-stressful subgroups (controls), thus increasing statistical power to detect effects of stress