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Studies have shown that long non-coding RNA (lncRNA), microRNA (miRNA) and DNA methylation, through various mechanisms to regulate the transcription of genes and proteins, and activate a series of molecular signal pathways to participate in the process of apoptosis [44,45,46](Table 1)

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Preventing that early inoculation requires a concerted societal and political strategy including school-based education, reduced media exposure, counter-marketing, tobacco and smoke free homes and public areas and youth access restrictions

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