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Next, TEER measurement was employed to assess the integrity of epithelial barrier through measuring their capacity to impede electric current applied across the epithelial layer, and apparent decrease of TEER was observed in CSE-exposed PBECs compared with normal cells, which was recovered by AZI concentration-dependently (Fig

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47 demonstrated that when lung tissue is subjected to cyclic stretch during CSE treatment, there is a significant increase in inflammatory cytokine IL-1 and proteolytic enzymes such as MMP-1, which are key contributors to emphysema progression