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There are many practical difficulties associated with subjects smoking in the modern neuroscientific laboratory environment, however electronic cigarettes obviate many of these issues, and provide a close simulation of smoking tobacco cigarettes

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Only 11% knew that none or only a small amount of smoking-related risk was due to nicotine (Office for Health Improvement and Disparities [OHID], 2022)

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Moreover, users absorb the nicotine derived from nicotine salt far more rapidly than from freebase nicotine