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Water-based solutions used improperly can push smoke particles deeper into the leathers pores, making extraction more challenging

Various in vitro , in vivo and case studies have suggested that heavy metals present in cigarettes of Indian origin may induces intracellular ROS accumulation and increased expression of PI3K, AKT, NFB, c-Myc which ultimately lead to unusual cell division or cancer (Mohapatra et al ., 2014)

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For those with schizophrenia they are three times more likely to smoke heavily