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doi: 10.1080/1462220412331320716

Gas exchange is directly impaired by reducing diffusing capacity (DLCO) and disrupting ventilation-perfusion matching, ultimately resulting in hypoxemia and ventilation/perfusion ratio (V/Q) imbalance (6466)

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Aoshiba and colleagues (2001) reported that toxic effects on isolated alveolar macrophages from the smoke of an unfiltered commercial cigarette involved oxidative stress, an important mediator of cell death through both necrosis and apoptosis

Test them with the same tobacco blend to isolate tube differences from tobacco variables