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Cyclophosphamide and ifosfamide The alkylating chemotherapy agents ifosfamide and cyclophosphamide are metabolised by CYP2B6, 2C9 and 3A4, all of which are induced by smoking [45]

A metallic taste in the mouth was the first sign that something was wrong, followed by a burning sensation in the throat, vomiting and muscle spasms

However, it is still more harmful than cigar smoking

(Hemingway, another newspaperman reluctant to seem so, credited Czanne with the birth of his own style.) Declaring himself not at all arty, Simenon then piled on arty antecedents as much as any avant-gardist