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The HOPE cohort was underrepresented in the youngest and oldest age groups (PR, 0.69 [95% CI, 0.69;0.70] and 0.75 [95% CI, 0.75;0.76]), among women born outside Denmark (PR, 0.58 [95% CI, 0.58;0.58]), among those giving birth to twins/triplets (PR, 0.80 [95% CI, 0.80;0.80]), and among women with 4 + children (PR, 0.64 [95% CI, 0.64;0.64])

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44 Despite these effects, randomized, controlled trials have found no significant increase in the incidence of cardiovascular events or mortality among patients with cardiovascular disease receiving NRT when compared with that of patients receiving placebo