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Health Conclusion.

The paperweight was produced on the occasion of the gift of the 'Caroline' to the Smithsonian.

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Our previous in vitro study revealed that chronic exposure to CSE-enhanced carbonic anhydrate II (CA II, early stage of osteoclastic differentiation [84]) and tartrate-resistant acid phosphatase 5b (TRAP 5b, later stage of osteoclastic differentiation [85]) activities in a bone co-culture system, resulting in an osteoporotic microenvironment [86]