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The rapid growth of manufacturing needs has outpaced the available skilled workforce in peptide chemistry and biologics production

In South Africa, Ozempic is only registered for treatment of type 2 diabetes and to reduce the risk of major adverse cardiovascular events, but it is also prescribed off-label for weight loss

Both drugs remain unaffordable for most patients without insurance or manufacturer savings programs

This suggests that while multiple lysine residues on YAP1 could be transiently modified, Lys254 serves as the major functional site mediating K63-linked ubiquitination and YAP1 stabilization